A functional unbalance of TRPM8 and Kv1 channels underlies orofacial cold allodynia induced by peripheral nerve damage

Cold allodynia is a debilitating symptom of orofacial neuropathic pain resulting from trigeminal nerve damage.The molecular and neural bases of this sensory alteration are still poorly understood.Here, using chronic constriction injury (CCI) of the infraorbital nerve (IoN) (IoN-CCI) in mice, combined with behavioral analysis, Ca2+ imaging and patch

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Boundary Point Measurement Using Visual Technique

The global positioning system real-time kinematic (GPS-RTK) instrument is a commonly used instrument to obtain GPS coordinates in cadastral surveying, but its HAPPYSENSE 100MG use is limited to unshielded environments.This study proposes a new method based on a visual simultaneous localization and mapping (SLAM) algorithm that uses a stereo-camera

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Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

Quorum Differential Cover sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases, siderophores, and toxins, as well as biofilm formation.Since the inhibition of this pathway reduces bacterial virulence, QS is considered a valuable candidate drug target, particularl

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